Oral therapy (pills) is the least effective and the most likely to be associated with liver problems, even though this is a small risk. This is related to the first-pass effect of all medications ingested via the digestive system. Once absorbed from the intesting, all food materials must pass through the hepatic (liver) system and be metabolized. As such, the actual delivery to the systemic blood system is low due to the liver metabolism of the testosterone. For this reason, the oral doses are quite high in order to get serum levels higher.


But some medications used to treat high blood pressure, such as beta blockers and diuretics, can also increase your risk of erectile dysfunction. While no one should stop taking blood pressure medicine without speaking to their doctor, making lifestyle changes, such as maintaining a healthy diet and getting more exercise may help lower your blood pressure so you don't need the drugs, Kramer said.

"Diseases and illnesses can hamper one's ability to achieve an erection," he explains. "Cancer, diabetes and heart disease is the cause in many cases. Low testosterone count caused by genetics, inactivity or unusual level of estrogen in the body can limit penile function as well." High blood pressure and high cholesterol can also be detrimental to erections.
Tadalafil shares the common side effects of the PDE5 inhibitors, however, due to its effect on PDE11, another phosphodiesterase located in muscle, tadalafil has been associated with muscle aches. Back pain and muscle aches occur in less than 7% of men taking tadalafil and in most patients will go away without treatment within 48 hours. When treatment was necessary, acetaminophen (Tylenol) and nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Motrin, Advil) or naproxen (Aleve) were effective. Rarely do the muscle aches and back pain cause men to stop using tadalafil.
Cardiovascular diseases: The most common cause of cardiovascular diseases in the United States is atherosclerosis, the narrowing and hardening of arteries that reduces blood flow. Atherosclerosis (a type of vascular disease) typically affects arteries throughout the body; hypertension, high blood cholesterol levels, cigarette smoking, and diabetes mellitus aggravate atherosclerosis. Hardening of the arteries to the penis and pelvic organs, atherosclerosis, causes insufficient blood flow into the penis. There is a close correlation between the severity of atherosclerosis in the coronary arteries and erectile dysfunction. For example, men with more severe coronary artery atherosclerosis (hardening of the arteries in the heart) also tend to have more erectile dysfunction than men with mild or no coronary artery atherosclerosis. Some doctors suggest that men with new onset erectile dysfunction undergo evaluation for silent coronary artery diseases (advanced coronary artery atherosclerosis that has not yet caused angina or heart attacks).

Me? I'm in my 60's and never had ED, not even once. And never failed to have a good orgasm with sexual activity. Unfortunately, I think it has created too much of a contrast to my wife, who has never had an orgasm, and now in menopause has given up and won't even let me touch her sexually (hugging and kissing is fine, but that's as far as she'll let me go).

What does zinc do for you sexually?


Are you reading article after article wondering how to put a stop to erectile dysfunction? There is no shame in suffering from erectile dysfunction, being as common condition as it is, erectile dysfunction is one of the leading health problems in men. The researchers suggest that every man will suffer from erectile dysfunction at some point of their life. So, if you have been wandering the Internet with the hope of finding out about the ways you could use to cure your condition, or if you want to get informed about the topic of erectile dysfunction, you are in the right place.

Is it OK to take viagra everyday?


Getting from a turn-on to a hard-on is a bit like dominoes: you experience stimuli, your brain relaxes the muscles in your penis, the arteries fill with blood, your penis closes off the blood’s escape route so it stays hard, and — voilà! Your erection is sustained. However, if even one of these dominoes isn’t lined up, things can go awry. Here’s a quick overview of just some of the issues that could be at play:

Several medications can interfere with the chemical processing of PDE5i medications by the liver. These can include ketoconazole (an antifungal medication known by the brand name Nizoral), erythromycin (an antibiotic), and cimetidine (also known as Tagamet, for reducing stomach acid). A lower dose of PDE5i medications should be used if one is taking any of these medications.
A study from the University of the West in the United Kingdom found that pelvic exercises helped 40 percent of men with ED regain normal erectile function. They also helped an additional 33.5 percent significantly improve erectile function. Additional research suggests pelvic muscle training may be helpful for treating ED as well as other pelvic health issues.
Erectile dysfunction (ED) is a common problem in men with heart disease. It is the repeated inability to obtain and maintain an erection of the penis. The inability to obtain an erection now and then is not necessarily cause for concern. But an ongoing problem can significantly affect your quality of life. Even more importantly, ED can sometimes be the first sign of a larger health problem, such as heart disease or diabetes.

Individuals at higher risk for priapism (painful erection lasting longer than six hours), including men with sickle cell anemia, thrombocytopenia (low platelet count), polycythemia (increased red blood cell count), multiple myeloma (a cancer of the white blood cells), and history of blood clots (for example, deep venous thrombosis [DVT]) or hyperviscosity (thick blood) syndrome are at increased risk for priapism with MUSE. 

Talk with your doctor about going to a counselor if psychological or emotional issues are affecting your ED. A counselor can teach you how to lower your anxiety or stress related to sex. Your counselor may suggest that you bring your partner to counseling sessions to learn how to support you. As you work on relieving your anxiety or stress, a doctor can focus on treating the physical causes of ED.
#5 Take time, don’t rush in. This is something most guys don’t know and don’t care to know. Foreplay always helps the guy hold on longer. You may think it’s pointless, but by indulging in foreplay for 15 minutes before penetration, your little guy would get more time to warm himself up for the act. Just don’t think about your erection until you have to penetrate her. And when it’s time, you can rest assured that he’ll be ready. [Read: The beginners guide to sexual role playing]

Can erectile dysfunction can be cured?


Vacuum devices: Specially designed vacuum devices to produce erections have been used successfully for many years. They are safe and relatively inexpensive. They work by creating a vacuum around the penis that draws blood into the penis, engorging it, and expanding it. There are three components to the device, a plastic cylinder in which the penis is placed, a battery or hand operated pump that draws air out of the cylinder creating the vacuum, and an elastic band (constriction device) that is placed around the base of the penis, to maintain the erection after the cylinder is removed and during intercourse by preventing blood from flowing out of the penis back into the body.
These exercises are helpful to build muscles, strength, increase blood flow and create a better approach to body control. Most of the gym exercises come under this category. These exercises are an important part of your erectile dysfunction treatment method and are highly beneficial in strengthening the control over penile organ. Some of the note-worthy exercises are given below;
Many common medications for treating hypertension, depression, and high blood lipids (high cholesterol) can contribute to erectile dysfunction (see above). Treatment of hypertension is an example. There are many different types (classes) of medications for high blood pressure; these include beta-blockers, calcium channel blockers, diuretics (medications that increase urine volume), angiotensin converting enzyme inhibitors (ACE inhibitors), and angiotensin receptor blockers (ARBs). Patients may use these medications alone or in combination to control blood pressure. Some of these medications can cause troubles with erections. For example, Inderal (a beta-blocker) and hydrochlorothiazide (a diuretic) cause erectile dysfunction, while calcium channel blockers and ACE inhibitors do not seem to affect erectile function. On the other hand, other medications (such as angiotensin receptor blockers [ARB] including losartan [Cozaar] and valsartan [Diovan]) may actually help with erections. Therefore, if possible, you may benefit from changing your medications, but this requires approval by your prescribing health care provider.
Self-injection of these agents has been of enormous benefit because they represent the most effective way to achieve erections in a wide variety of men who otherwise would be unable to achieve adequate rigid erections. The need for intact nerve pathways to the penile tissue is not needed. The locally injected medication directly relaxes the arteriole vessels and penile cavernosal tissue. Thus, this therapy is not dependent on sexual stimulation.

Obesity and metabolic syndrome can cause changes in blood pressure, body composition, and cholesterol which may lead to ED. Other conditions that may contribute to erectile dysfunction include Parkinson’s, multiple sclerosis, Peyronie’s disease, sleep disorders, alcoholism, and drug abuse. Taking certain medications can also increase your risk for ED.


For more information, check out the related Q&As. And while you're determining the cause of your partner's ED, you can still be intimate with activities other than intercourse that you both enjoy. As an exercise, you can try focusing on non-genital sensations, such as kissing and cuddling. You can also pleasure by caressing, touching, and stroking one another, having oral sex, or incorporating sex toys into your sex play. What non-intercourse intimacies do you enjoy? What about your partner? Have you discussed all the things you like that don't require an erection? Enjoying each other's company might give you both the emotional support and physical intimacy you need to help maintain a spark and eventually get the fire going again. Good luck,
What do the gums and the penis have in common? Having periodontitis chronically inflamed and infected gums may increase your risk of erectile dysfunction, according to a study published in June in the Journal of Sexual Medicine. The study, performed in mice, suggests a link between gum disease and ED , but the connection in humans and the mechanism by which periodontitis may lead to ED is still unclear.

Erectile dysfunction is a condition in which a man can't get or keep an erection that's hard or long enough to have sex. Every man occasionally experiences the inability to get an erection, and that's perfectly normal. However, if it's something that happens frequently, it's called erectile dysfunction (ED). ED can be caused by a number of physical and psychological factors, and its symptoms can range from mild to severe. Fortunately, there are many options for treating this condition.
A number of treatments are available to treat erectile dysfunction. The typical treatment strategy starts with simple to use, noninvasive therapies and progresses to more invasive surgical therapies as needed. In all men, the first step is determining if there are any modifiable risks factors that can either improve or prevent progression of erectile dysfunction. Since the risk of developing ED is increased in the presence of diabetes, heart disease, and hypertension, it is thought that better control/prevention of these conditions may have a benefit in ED. Similarly, it is thought that lifestyle modifications to improve vascular function such as avoiding smoking, maintaining ideal body weight, and engaging in regular exercise might either prevent or reverse ED. Sexual counseling may also be useful in addressing relationship stressors as you work on improving your erectile function.

Vitamin D deficiency has been linked with rickets, cancer, cardiovascular disease, severe asthma in children and cognitive impairment in older adults. Causes include not ingesting enough of the vitamin over time, having limited exposure to sunlight, having dark skin, and obesity. Symptoms include bone pain and muscle weakness. Treatment for vitamin D deficiency involves obtaining more vitamin D through supplements, diet, or exposure to sunlight.

I know. You probably already know that being overweight is bad for your health. But, did you know that being overweight actually causes your body to turn testosterone into estrogen? This is one of the reasons scientists believe obesity and a sedentary lifestyle (little to no exercise, unhealthy food choices, etc.) lead to problems with erectile dysfunction.
The PDE5 inhibitors sildenafil (Viagra), vardenafil (Levitra) and tadalafil (Cialis) are prescription drugs which are taken by mouth.[24]:20–21 As of 2018, sildenafil is available in the UK without a prescription.[28] Additionally, a cream combining alprostadil with the permeation enhancer DDAIP has been approved in Canada as a first line treatment for ED.[29] Penile injections, on the other hand, can involve one of the following medications: papaverine, phentolamine, and prostaglandin E1, also known as alprostadil.[24] In addition to injections, there is an alprostadil suppository that can be inserted into the urethra. Once inserted, an erection can begin within 10 minutes and last up to an hour.[25] Medications to treat ED may cause a side effect called priapism.[25]

But don’t panic. ED can be caused by a number of factors, from depression and medication side effects to high blood pressure, high cholesterol, low testosterone levels, Peyronie’s disease, nerve damage, performance anxiety, heart disease, diabetes, and more. Even better, many of these ED causes are treatable with medication and simple lifestyle changes. It’s important to know the root cause of your erectile dysfunction in order to treat it in the fastest, most effective way possible. Here are the 5 most common causes of erectile dysfunction.

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